You are here

TSNA exposure: Levels of NNAL among Canadian tobacco users

TitleTSNA exposure: Levels of NNAL among Canadian tobacco users
Year of Publication2014
AuthorsCzoli, C. D., and Hammond D.
JournalNicotine and Tobacco Research
Volume2014
Pages1 - 6
Abstract

Introduction: Tobacco smoke contains more than 7,000 chemicals, including known carcinogens, such as tobacco-specific nitrosamines (TSNAs). TSNA levels in cigarettes vary considerably within and across markets; however, the extent to which these different TSNA levels translate into differences in human exposure and risk remains unclear. The current study sought to examine TSNA exposure among Canadian tobacco users. Methods: Data from the 2007-2009 Canadian Health Measures Survey were used to measure levels of urinary NNAL [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol], a metabolite of the TSNA NNK [4-(methylnitrosamino-1-(3-pyridyl)-1-butanone], among tobacco users (n = 507). Geometric mean concentrations of total urinary NNAL and creatinine-corrected total urinary NNAL were calculated. A linear regression model was used to examine predictors of urinary levels of NNAL. Results: The mean population level of total urinary NNAL and creatinine-corrected total urinary NNAL was 71.2 pg/ml and 82.0 pg/mg creatinine, respectively. NNAL levels were higher among older respondents (p = .02), among females (p = .04), and among those with greater daily cigarette consumption (p

URLhttp://ntr.oxfordjournals.org/content/early/2014/12/20/ntr.ntu251.abstract
DOI10.1093/ntr/ntu251
Document URLhttp://ntr.oxfordjournals.org/content/early/2014/12/20/ntr.ntu251.full.pdf+html