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Maternal history of asthma modifies the risk of childhood persistent asthma associated with maternal age at birth: Results from a large prospective cohort in Canada

TitleMaternal history of asthma modifies the risk of childhood persistent asthma associated with maternal age at birth: Results from a large prospective cohort in Canada
Year of Publication2019
AuthorsWadden, D., Farrell J., Smith M. Jane, Twells L. K., and Gao Z.
JournalJournal of Asthma
VolumeePub ahead of Print
Pages1 - 8
Keywordsasthma, canada, childhood
Abstract

{Background: Asthma is a prevalent disease that affects many Canadians. Persistent asthma can affect quality of life, and has multiple health implications. Maternal age at birth has been associated with many adverse health outcomes in children. Conflicting study results exist regarding maternal age at birth and childhood asthma. The association between maternal age at birth and persistent asthma in children is still unknown. Objective: To investigate the relationship between maternal age at birth and persistent asthma in children at ten years of age. Methods: This is a prospective cohort study including all children aged 0-2 years who took part in the first cycle of the National Longitudinal Survey of Children and Youths (NLSCY) and were followed every two years until eight to ten years of age in Cycle 5. An interaction term between maternal age at birth and maternal asthma history was introduced in a multivariate model to examine modification effects of maternal asthma history on the association. Results: Multivariate logistic regression demonstrated that older maternal age at birth was significantly associated with an increased risk of childhood persistent asthma in mothers with a history of asthma (OR = 1.20, 95% CI: 1.04-1.40

URLhttps://www.tandfonline.com/doi/full/10.1080/02770903.2019.1658207
DOI10.1080/02770903.2019.1658207
Document URLhttps://www.tandfonline.com/doi/pdf/10.1080/02770903.2019.1658207