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Long-term trends in the incidence and relative survival of pancreatic cancer in Canada: A population-based study

TitleLong-term trends in the incidence and relative survival of pancreatic cancer in Canada: A population-based study
Year of Publication2016
AuthorsAkhtar-Danesh, G-G., Finley C., and Akhtar-Danesh N.
JournalPancreatology
Volume16
Pages259 - 265
Keywordscancer registry, excess mortality rate, incidence rate, pancreatic cancer, population-based study, relative survival
Abstract

BACKGROUND/OBJECTIVE: The poor survival among pancreatic cancer patients accounts for a disproportionate number of cancer deaths, and there has been little or no improvement in the long-term survival of these patients. This study examines the long-term trends in incidence and relative survival of patients diagnosed with pancreatic cancer in Canada between 1992 and 2008. METHODS: We used pancreatic cancer data from the Canadian Cancer Registry. Incidence rate per age group was estimated over the aforementioned period. A flexible parametric model was used to estimate trends in one- and five-year relative survival for each age group and sex. Excess mortality rate was estimated to illustrate additional mortality due to a cancer diagnosis. RESULTS: In total, 34,577 patients with pancreatic cancer were identified, of which 49.3% were male. Mean age at diagnosis was 70.1 (SD = 12.3) years. Approximately 60.0% of patients were older than 70 years at diagnosis. There has been no change in the incidence rate of pancreatic cancer in Canada; however, it significantly decreased for men (80+) (p = 0.011). Although one-year relative survival increased over time for all patients, five-year relative survival increased only 5% for the youngest age group (

URLhttp://www.pancreatology.net/article/s1424-3903(16)00005-3/abstract
DOI10.1016/j.pan.2015.12.180
Document URLhttp://www.pancreatology.net/article/s1424-3903(16)00005-3/fulltext