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Carcinogen exposure among Canadian tobacco users: Changes in NNK Exposure from 2007–2009 through 2012–2013

TitleCarcinogen exposure among Canadian tobacco users: Changes in NNK Exposure from 2007–2009 through 2012–2013
Year of Publication2018
AuthorsCzoli, C. D., and Hammond D.
JournalCancer Epidemiology, Biomarkers and Prevention
Volume27
Pages262 - 267
Abstract

Background: Tobacco-specific nitrosamines (TSNAs) are a class of carcinogens found in tobacco products, whose levels can vary considerably depending on tobacco blends and manufacturing processes. The current study examined whether recent increases in levels of the TSNA NNK [4-(methylnitrosamino-1-(3-pyridyl)-1-butanone] in Canadian cigarettes translated into differences in exposure among Canadian tobacco users. Methods: Nationally representative data from the Canadian Health Measures Survey (CHMS) were used to measure levels of total urinary NNAL [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol], a metabolite of the TSNA NNK, among tobacco users. Data from CHMS Cycle 3 (2012–13) were used to examine NNAL, and linear regression was used to examine predictors. Data from CHMS Cycle 1 (2007–09) and Cycle 3 (2012–13) were used to examine changes in NNAL over time. Results: From 2007–2009 through 2012–2013, levels of creatinine-corrected NNAL increased by 64% (P

URLhttp://cebp.aacrjournals.org/content/27/3/262
DOI10.1158/1055-9965.EPI-17-0715
Document URLhttp://cebp.aacrjournals.org/content/27/3/262.full-text.pdf