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Birth weight, stress and symptoms of depression in adolescence: Evidence of fetal programming in a national Canadian cohort

TitleBirth weight, stress and symptoms of depression in adolescence: Evidence of fetal programming in a national Canadian cohort
Year of Publication2012
AuthorsColman, I., Ataullahjan A., Naicker K., and Van Lieshout R. J.
JournalCanadian Journal of Psychiatry
Volume57
Pages422 - 428
Keywordsbirth weight, depression, epidemiology, fetal distress, stressful events
Abstract

To investigate evidence of fetal programming in humans by studying whether adolescents born at high or low birth weights (LBW) are more likely to experience symptoms of depression and anxiety after experiencing stress. METHOD: The sample included 3732 members of a prospective Canadian cohort study assessed for symptoms of depression and anxiety at age 12 to 15 years (2006/2007), and had birth weight and gestational age (GA) data recorded in 1994/1995. Major stressful life events and chronic stressors were also reported throughout childhood. RESULTS: After adjusting for acute and chronic stress, being born small for GA (SGA) (OR 1.50; 95% CI 1.08 to 2.08) or large (OR 1.31; 95% CI 0.99 to 1.72) for GA was associated with an increased risk of depression and anxiety in adolescence, compared with adolescents who were born at a weight appropriate for their GA. Most interactions between birth weight and stress were not significant; however, the relation between chronic stress and adolescent depression and anxiety was more pronounced in males who were born SGA (interaction P

URLhttp://www.ncbi.nlm.nih.gov/pubmed/22762297 http://publications.cpa-apc.org/browse/documents/567
Document URLhttp://publications.cpa-apc.org/media.php?mid=1317