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A genetic model for multimorbidity in young adults

TitleA genetic model for multimorbidity in young adults
Year of Publication2020
AuthorsMalecki, S. L., Van Mil S., Graffi J., Breetvelt E., Corral M., Boot E., Chow E. W. C., Sanches M., Verma A. A., and Bassett A. S.
JournalGenetics in Medicine
Pages132 - 141
Keywordsdigeorge syndrome, drug therapy, multiple chronic conditions, noncommunicable diseases, rare genetic disorders

{Purpose Multimorbidity is increasing in younger adults but is understudied in this population. We used 22q11.2 deletion syndrome (22q11.2DS) as a genetic model to investigate multimorbidity in young to middle-aged adults. Methods Using the Anatomical Therapeutic Chemical (ATC) Classification System and setting five or more concurrent prescription medications as a proxy for multimorbidity, we compared data on 264 adults with 22q11.2DS (median age 27.8, range 17.3-68.3 years) with that for a community-based Canadian general population sample (n = 25,287). We used logistic regression to examine possible predictors of multimorbidity in 22q11.2DS. Results Multimorbidity in 22q11.2DS in the 25-44 year age group (34.7%) was significantly more prevalent than in the general population, both for the same age group (2.9%, prevalence ratio [PR] = 11.9, 95% CI 8.4-17.1) and compared with those aged 45-64 years (16.4%